2:1 ratios have a reduced psychoactivity. However, this ratio works for those who can tolerate THC. This ratio provides relaxation, euphoria, calmness, and tranquility. Psychoactive effects can especially be felt when taken at larger doses. For most people, this ratio is best for those with pain, insomnia, and stress. Breath in fast-acting CBD relief. Care By Design vape cartridges work with a standard vape pen and battery. Ideal for quick relief.